Metabolism of 11-oxygenated steroids. 2. 2-Methyl steroids

Metabolism of 11-oxygenated steroids. 1. Influence of the A/B ring junction on the reduction of 11-oxo groups.

Hypertension and excretion of 1-Oxygenated steroids.

Congenital adrenal hyperplasia with failure of 11-hydroxylation (Eberlein and Bongiovanni, 1956) produces virilization and hypertension. The newborn girl reported here was originally thought to have this condition, but investigations revealed an abnormal steroid excretion of a type not previously described. In retrospect it was realized that the type of abnormal steroid which she produced had b...

Metabolism of anabolic androgenic steroids.

Anabolic androgenic steroids (AAS) are misused to a high extent in sports by athletes to improve their physical performance. Sports federations consider the use of these drugs in sports as doping. The misuse of AAS is controlled by detection of the parent AAS (when excreted into urine) and (or) their metabolites in urine of athletes. I present a review of the metabolism of AAS. Testosterone is ...

11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome

Context Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS. Methods On...

Metabolism of C-16-oxygenated steroids by human placenta: the formation of estriol.

Two distinct pathways for the formation of estriol in vitro have recently been described: C-16 hydroxylation of estradiol-17-P by human fetal liver and rat liver (1, 2), and aromatization of A5-androstene-3/?, 16a, 17&triol by human placenta (3). Although the formation in viva of estriol from estradioll and estrone is well known (4), the studies mentioned above present the first convincing data...